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Spatial Biology Two Times Faster
The combination of rapid fluidics, multi-slide automation, and parallel image processing make the PhenoCycler-Fusion 2.0 the fastest spatial biology solution.
Experience the fastest spatial biology solution
In the ever-evolving landscape of spatial biology research, speed is essential to unlocking new discoveries.
The PhenoCycler-Fusion 2.0 is the fastest spatial biology solution. Trusted by leading academic and industry innovators, this next-generation platform accelerates discoveries and breakthroughs in immunology, oncology, neuroscience, and beyond.
How the PhenoCycler-Fusion 2.0 works
The PhenoCycler-Fusion 2.0 combines automated fluidics with high-speed imaging to generate high-resolution, multiplexed images of whole-slide tissue sections—streamlining complex spatial proteomics workflows into an intuitive, automated process.
The platform uses a single staining step followed by automated reveal-image-remove cycles with fluorescently labeled antibodies. This process continues until every biomarker in the panel is imaged—ensuring comprehensive coverage without manual intervention.
Each antibody is tagged with a unique oligonucleotide barcode, enabling seamless scaling to over 100 biomarkers identified and quantified on the same tissue section. This ensures flexibility for expanding panels without compromising image quality or workflow simplicity.
Using automation and parallel fluidics, high-resolution images of multiple samples and from different panels can be run simultaneously to significantly reduce the time to complete experiments.
The PhenoCycler-Fusion 2.0 software produces high-resolution images at manageable data sizes. The instrument utilizes the QPTIFF format, ensuring effortless compatibility with various software solutions for downstream spatial data analysis.
Don’t worry about variable sample types or matching panels to the same sample type for multislide runs. The scenarios below are examples of the flexibility achievable with the PhenoCycler-Fusion.
Different sample formats in a single run
Effortlessly phenotype a large tonsil tissue sample on one slide while accommodating 300 core samples on a tissue microarray (TMA) on a second slide.
Different tissue types in a single run
Seamlessly phenotype skin and lung tissue samples on a single slide while a second slide has two additional skin tissue samples.
Two panels in a single run
Phenotype a 25-plex core immune marker panel on a tonsil tissue one one slide while simultaneously phenotyping a 25-plex core and proliferation panel on a non-small cell lung cancer sample on a second slide.
Two large samples from different tissues in a single run
Dive into the intricacies of different tissue types by phenotyping a large tissue on each slide.
Publications featuring the Akoya PhenoCycler-Fusion 2.0
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