Simoa technology is unique in its ability to simultaneously and precisely measure multiple cytokines down to baseline levels, enabling scientists to uncover a unique and comprehensive understanding of SARS-CoV-2 pathogenesis and host response.
The use of Simoa® technology to measure cytokines in both singleplex and multiplex configurations with excellent precision and limits of detection in the low fg/mL or sub–fg/mL levels, allowing robust quantification well below what is possible today.
Sprague et al.
Researchers used Simoa assays to detect toxins in plasma secreted by Clostridioides difficile during infection and found that circulating antitoxin antibodies may play a role in the absence of host toxemia.
Zhang et al.
In patients with severe COVID-19 pneumonia, researchers identified loss of function variants in 13 human loci that regulate TLR3- and IRF7-dependent type I IFN immunity to influenza virus. The impact of these mutations on fibroblasts suggests susceptibility to SARS-CoV-2, demonstrating the potential role of inborn errors of type I IFN immunity in severe cases of COVID-19.
Neurology
Poster Background Developing effective therapies for glioblastoma (GBM) relies on robust preclinical animal models that enable detailed investigation of tumor biology, discovery of therapeutic targets, and evaluation of new treatment…
Oncology
Poster Background Ultrahigh-Plex Single-cell Spatial Phenotyping has revealed valuable insights into the tumor immune microenvironment (TiME) for biomarker discovery and stratification of clinical responses. Metabolic reprogramming is a key hallmark…
Neurology
Alzheimer’s Research and Therapy | August 26, 2024 Sampani K, Ness S, Tuz-Zahra F, Aytan N, Spurlock EE, Alluri S, Chen X, Siegel NH, Alosco ML, Xia W, Tripodis Y,…
Neurology
Poster The intersection of new therapeutic options for Alzheimer’s disease (AD), the emergence of accurate blood-based tests for AD, and the anticipated health system log jam for confirmatory diagnostic testing…
Neurology
Alzheimer’s & Dementia | August 3, 2024 Verberk IMW, Jutte J, Kingma MY, Vigneswaran S, Gouda MMTEE, van Engelen MP, Alcolea D, Arranz J, Fortea J, Lleó A, Chevalier C,…
Neurology
Journal of Lipid Research | August 2, 2024 Becktel DA, Frye JB, Le EH, Whitman SA, Schnellmann RG, Morrison HW, Doyle KP. J Lipid Res. 2024 https://doi.org/10.1016/j.jlr.2024.100614 Abstract Ischemic stroke…
Simoa, an ultra-sensitive immunoassay technology allows detection of proteins and nucleic acids at lowest possible levels.
