Why Choose the Human Neurobiology PhenoCode Discovery Panel?
- Disease-specific insights—detect neurodegenerative protein aggregates associated with Alzheimer’s disease and Parkinson’s disease, track inflammation-driven pathology, and assess blood-brain barrier integrity disruptions.
- Scalable: Expand and customize the panel by adding additional biomarkers using our PhenoCode 2.0 Molecular Barcoding Kit
- Speed—use an optimized, ready-to-use panel to spatially phenotype human brain formalin-fixed paraffin-embedded (FFPE) tissues.
- Multi-Omics Compatible: Gentle chemistry preserves tissue quality to support additional ‘omics analyses on the same tissue section without limiting plexing
Fast
Designed for the fastest spatial biology solution
Optimized
Ultrahigh-plex, ready-to-use panel for easy implementation
Customizable
Add additional biomarkers to expand to over 100 plex
Biomarkers included in the Panel
The Human Neurobiology Panel includes biomarkers associated with neuroinflammatory and neurodegenerative processes, including those relevant to Alzheimer’s disease and Parkinson’s disease. The panel has been tested on human FFPE brain tissue, ensuring robust performance in commonly used preclinical sample types. For other tissue preparations or preclinical models, our Spatial Accelerator Laboratory Services team offers custom assay development, sample testing, and sample testing studies to assess panel performance for your specific translational needs.
| Neuronal cells | |
|---|---|
| Mature neurons | MAP2 NeuN Neurofilament-L Synaptophysin |
| GABAergic neurons | GABA |
| Cholinergic neurons | CHAT |
| Serotonergic neurons | Serotonin |
| Neurodegenerative disease markers | |
|---|---|
| Alzheimer’s disease | Amyloid-beta ApoE p-Tau 181 p-Tau 205 p-Tau 231 p-Tau 396 |
| Parkinson’s disease and synucleinopathies | Alpha-synuclein |
| General neurodegeneration | H2A.X |
| Neuroinflammation and immune response | |
|---|---|
| Microglia | TMEM119 |
| Activated microglia and macrophages | CD68 Galectin-3 Iba1 |
| T cell infiltration | CD3e CD4 CD8 |
| General immune activation | CD14 CD163 CD44 CD45 HLA-A HLA-DR iNOS |
| Astrocyte-associated inflammation | GFAP |
| Neuroplasticity and cellular remodeling | |
|---|---|
| Proliferation and neurogenesis | Ki67 PCNA |
| Astrocyte and structural plasticity | S100B Vimentin |
| Oligodendrocytes | MBP Olig2 |
| Blood-brain barrier integrity and vascular components | |
|---|---|
| Endothelial cells and vascular structure | CD31 CD34 Claudin-5 Collagen IV |
| Pericytes and smooth muscle cells | SMA |
| Astrocyte-endothelial interactions | AQP4 |
Human Neurobiology PhenoCode Discovery Panel
Panel of 42 neuroscience biomarkers comprising antibodies and reporters.
Size
Up to 25 slides
Catalog number
STPHNP001
Human Neurobiology PhenoCode Discovery Starter Pack
The Human Neurobiology PhenoCode Discovery Panel plus PhenoCycler-Fusion consumables for a complete solution to spatially phenotype 42 neuroscience biomarkers.
Size
Up to 20 slides
Catalog number
STPHNP001_R
Documents
Visualize the brain’s molecular map
Take the next step toward high-impact discoveries—request your quote and start exploring 42 key neuroscience biomarkers in spatial context.
