Why Choose the Mouse Neurobiology PhenoCode Discovery Panel?
Fast, Ready-to-use: Optimized for mouse FFPE tissue on the Akoya PhenoCycler-Fusion 2.0 to deliver rapid, reproducible, high-plex imaging
Translational: Designed around human disease-relevant biomarkers, seamlessly transition from mouse to human with our Human Neurobiology PhenoCode Discovery Panel for continuity across preclinical and clinical neuroscience
Multi-Omics Compatible: Gentle chemistry preserves tissue quality to support additional ‘omics analyses on the same tissue section without limiting plexing
Scalable: Expand and customize the panel by adding additional biomarkers using our PhenoCode 2.0 Molecular Barcoding Kit
Biomarkers Included in the Panel
The Mouse Neurobiology Panel includes biomarkers associated with neuroinflammatory and neurodegenerative processes, including those relevant to Alzheimer’s disease and Parkinson’s disease. The panel has been tested on mouse FFPE brain and spinal cord tissue, ensuring robust performance in commonly used preclinical sample types. For other tissue preparations or preclinical models, our Spatial Accelerator Laboratory Services team offers custom assay development, sample testing, and sample testing studies to assess panel performance for your specific translational needs.
| Neuronal Cell Type Markers | |
|---|---|
| Mature neurons |
NeuN |
| GABAergic neurons | GABA |
| Cholinergic neurons | CHAT |
| Serotonergic neurons | Serotonin |
| Neuroinflammation and Immune Response | |
|---|---|
| Microglia | TMEM119 |
| Activated Microglia and Macrophages |
Iba1 |
| T cell infiltration | CD3e CD4 CD8 |
| General immune activation | CD44 CD45 CD20 MHC II Ter119 |
| Astrocyte-associated inflammation | GFAP |
| Neurodegenerative Disease Markers | |
|---|---|
| Alzheimer’s disease | Amyloid-beta APOE Tau (phospho T181) Tau (phospho T231) Tau (phospho S396) Tau (phospho T205) |
| Parkinson’s disease and Synucleinopathies | Alpha-synuclein |
| General neurodegeneration | H2A.X |
| Neuroplasticity and Cellular Remodeling | |
|---|---|
| Proliferation and Neurogenesis | Ki67 PCNA |
| Astrocyte and Structural Plasticity | S100B Vimentin |
| Oligodendrocytes and Myelination | MBP Olig-2 |
| Blood-Brain Barrier Integrity and Vascular Components | |
|---|---|
| Endothelial Cells and Vascular Structure | CD31 Claudin-5 Col1A1 |
| Pericytes and Smooth Muscle Cells | SMA |
| Astrocyte-Endothelial Interactions | AQP4 |
Explore our database of validated antibodies to streamline adding additional biomarkers.
Key Research Applications:
Interrogate neuroinflammatory responses: Characterize microglia activation states and astrocyte reactivity to explore spatial patterns of inflammation across CNS tissue
Map neuronal integrity and degeneration: Assess neuronal loss and stress to study pathways underlying neurodegenerative processes in transgenic mouse models
Resolve cell-to-cell interactions in nervous systems: Examine spatial relationships between neurons, glia, and immune cells to uncover how cellular crosstalk shapes disease progression; construct cellular atlases
Profile tissue remodeling: Track changes in myelination, structural proteins, and regenerative responses following injury or disease
Support target discovery and validation: Link cell-specific protein expression and spatial patterns to identify therapeutic targets and patient populations in preclinical models
Evaluate pharmacodynamic response: Assess how therapeutic interventions modulate cell states and the tissue microenvironment in preclinical mouse models
Discover how the Mouse Neurobiology PhenoCode Discovery Panel revealed immune and neuronal microenvironment relationships in a mouse model of glioblastoma.
The panel is available in two configurations:
Mouse Neurobiology PhenoCode Discovery Panel
Purchase only the 42-marker Mouse Neurobiology Discovery Panel, which includes antibodies and reporters. The panel supports up to 25 slides at a 1:200 dilution.
Mouse Neurobiology PhenoCode Discovery Starter Pack
The starter pack includes the Mouse Neurobiology PhenoCode Discovery Panel plus PhenoCycler-Fusion consumables for a complete solution to spatially phenotype 42 neurobiology biomarkers. The starter pack supports up to 20 slides.
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