VEGF-D is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4) and encoded by the FIGF gene. Vascular endothelial growth factor (VEGF) is a 27KDa signaling protein produced by cells that stimulates vasculogenesis and angiogenesis. VEGF is a heparin binding protein and exists as a disulfide linked homo-dimer. It has at least 6 isoforms produced by alternative splicing. VEGF induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels.