MIP-4 (PARC)

MIP-4 (macrophage inflammatory protein-4) also known as CCL18 is a small chemokine of the CC chemokine family that encodes an 89 amino acid residue precursor protein. MIP-4 is produced nd secreted mainly by the innate immune system. MIP-4 is highly expressed in lung and placenta but is not expressed in epidermal Langerhans cells. Recombinant MIP-4 has been shown to chemoattract naïve T cells but not monocytes or neutrophils.