RANKL also known as TRANCE (TNF-related activation induced cytokine), is a type II membrane protein that is a member of the TNF (tumor necrosis factor) family. RANKL is also referred to as NSF11 and functions as an inductor of osteoclastogenesis, lymph node organogenesis, enhancement of T cell growth, and dendritic cell function. Osteoprotegerin is a naturally occurring decoy receptor that counterbalances the effects of RANKL.

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