OPN (Osteopontin)

OPN (Osteopontin)

Osteopontin is a secreted molecule that belongs to a family of non-collagenous matricellular proteins. It functions as a ligand to αvβ3 integrin and possibly other receptors. It binds tightly to hydroxyapatite and can act as a structural component of the extracellular mineralized matrix. Osteopontin is initially secreted as a 298 amino acid protein, which is subject to multiple post-translational modifications including glycosylation, phosphorylation, and specific proteolytic cleavages into various smaller molecular weight fragments. Osteopontin is expressed in a wide range of cells and tissues including osteoblasts, various tumor cell lines, extraosseous cells in the inner ear, brain, kidney, deciduum, placenta and odontoblasts. 

 

Safety Data Sheets

The following Safety Data Sheets are associated with this Assay.