The UmanDiagnostics NF-light® test uses two highly specific non-competing monoclonal antibodies. One is immobilized on a solid phase and catches the neurofilament light (NFL) in solution. The other antibody acts as detector which interacts with the bound protein and gives rise to a signal through biotin – horseraddish peroxidase avidin binding. The signal obtained from the standard curve corresponds directly to the amount of NF-L. NF-light® ELISA is an invitro diagnostic device intended for quantitative determinations of human Neurofilament light (NF-L) protein in cerebrospinal fluid (CSF). The result is used to aid the diagnosis of neurological diseases such as amylotrophic lateral sclerosis (ALS), multiple sclerosis (MS), dementias and Parkinson’s disease (PD).

The kit is intended for professional use. In addition, the NF-light® ELISA can be used for research using samples containing NF-L from rat, bovine and macaque sources as the antibodies in the assay recognizes NF-L from these species as well.

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