MCP-3

MCP-3

Human monocyte chemotactic protein-3 is a 99 residue, 11 kDa secreted protein which shares 73% sequence similarity to its most structurally and functionally related homolog, MCP-1. MCP-3 displays strong interaction with CC chemokine receptor 2 (CCR2). Chemotactic gradients of MCP-3 are generated in response to localized cell infection which sequesters phagocytes to the site of inflammation2 and MCP-3 has been well implicated in the process of inflammation in response to presence of allergen. Elevated MCP-3 levels are associated with cytokine stimulated human osteosarcoma (cell line MG-63) and have been documented in patients with inflammatory bowel disease (IBD), ulcerative colitis, and Crohn’s disease. Faulty MCP-3 immune stimulation of non-inflamed lesioned areas of the CNS has been reported in patients with MS.

Safety Data Sheets

The following Safety Data Sheets are associated with this Assay.

Certificates of Analysis

The following Certificates of Analysis are associated with this Assay.