Human monocyte chemotactic protein-3 is a 99 residue, 11 kDa secreted protein which shares 73% sequence similarity to its most structurally and functionally related homolog, MCP-1. MCP-3 displays strong interaction with CC chemokine receptor 2 (CCR2). Chemotactic gradients of MCP-3 are generated in response to localized cell infection which sequesters phagocytes to the site of inflammation2 and MCP-3 has been well implicated in the process of inflammation in response to presence of allergen. Elevated MCP-3 levels are associated with cytokine stimulated human osteosarcoma (cell line MG-63) and have been documented in patients with inflammatory bowel disease (IBD), ulcerative colitis, and Crohn’s disease. Faulty MCP-3 immune stimulation of non-inflamed lesioned areas of the CNS has been reported in patients with MS.

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