M-CSF

M-CSF

M-CSF is a secreted cytokine that is a primary regulator of macrophage survival, proliferation, and differentiation. M-CSF is responsible for the differentiation of HSCs to macrophages and other similar cell types, and is essential for the survival and proliferation of osteoclast progenitors. M-CSF is clinically used in the treatment of infection, malignancies, and atherosclerosis and in facilitating hematopoietic recovery after bone marrow transplantation.