Interleukin 36 beta

Interleukin 36 beta (IL-36β, IL-1F8) is a member of the IL-1 family of cytokines. The inflammatory activity of IL-36β occurs through indirect activation of the NF-kappaB and MAPK pathways. This activation occurs via the intermediary Interleukin-1 receptor and accessory proteins (IL-1Rrp2 and IL-1RAcP, respectively). IL-36α, IL-36β, and IL-36γ are associated with the immune system in the skin. These cytokines directly activate keratinocytes and antigenpresenting cells and indirectly activate T cells to cause psoriasis. In primary human joint cells (synovial fibroblasts and articular chondrocytes) IL-36β exerts proinflammatory effects, but serum levels of IL-36β do not correlate with joint inflammation.

Safety Data Sheets

The following Safety Data Sheets are associated with this Assay.

Certificates of Analysis

The following Certificates of Analysis are associated with this Assay.

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