Infectious Disease

 
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Infectious Disease

Powering Precision Epidemiology

Research organizations around the world are deploying Simoa to combat COVID-19 and future pandemics with a full range of products, applications, and services including those listed below. In particular, Simoa’s extreme sensitivity and specificity is enabling researchers to measure cytokine levels and profiles in non-critical and critical COVID-19 patients as well as asymptomatic and symptomatic patients. 

We are actively seeking partners to work with us to develop viral loading and host immune response assays for both symptomatic and pre-symptomatic patients.  Let us know if you have ideas, assays and/or key reagents that could be combined with Simoa’s ultra-sensitivity.  

View our recent webinar to learn more about our efforts to prioritize support for COVID-19 research.

Studying the Key Role of Inflammation in Disease Progression and Severity
Studying the Key Role of Inflammation in Disease Progression and Severity

  • Up-regulation and suppression of Type I and Type II interferons (IFNα, IFNγ) as early predictors of disease severity
  • Pro-inflammatory cytokines (GM-CSF, IL-2, IL-6, IL-10, IL-12p70, TNFα) for early detection of imbalanced Th1 and Th2 response and risk for severe cytokine release
  • Biomarkers of chronic airway inflammatory disease (IL-4, IL-5, IL-13)
  • Airway remodeling (MMP-9) in virus-induced chronic pulmonary disease

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Characterizing Links between Viral Infection and Neurological Manifestations
Characterizing Links between Viral Infection and Neurological Manifestations

  • The role of circulating and CNS levels of chemokines (Eoxtaxin, IP-10, MCP-1) in neuroinflammation
  • Multiplex measurement of serum and plasma-based biomarkers of neurodegeneration (NF-l, GFAP, UCH-L1, tau)
  • Detection of biomarkers from dried blood spots enables use of remote sample collection protocols

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Measuring the Earliest Biomarkers of Myocardial Injury and Risk of Acute and Chronic Cardiac Disease
Measuring the Earliest Biomarkers of Myocardial Injury and Risk of Acute and Chronic Cardiac Disease

  • Ultra-sensitive measurement of changes in baseline levels of cardiac troponin I (cTnI) for determining risk of Acute Coronary Syndrome
  • Detection of natriuretic peptides (NT-proBNP) in monitoring chronic cardiac disease in COVID-19

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Developing New Ultra-Sensitive Assays for Viral Detection and Host Response
Developing New Ultra-Sensitive Assays for Viral Detection and Host Response

  • Quanterix’ unique homebrew ultrasensitive assay development capabilities provide the flexibility for researchers to develop singleplex and multiplex custom Simoa assays
  • Viral protein detection with PCR-level sensitivity with the speed and convenience of immunoassays
  • Serological assays to for characterizing host immune response, surveillance and vaccine development
  • Direct detection of nucleic acids using Simoa homebrew assay reagents to enable measurement of pathogen DNA and host miRNA biomarker levels without extraction or amplification

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Prioritized Access to CLIA-licensed Quanterix Accelerator Lab Services

Our CLIA-licensed Accelerator Services Laboratories harness our ultra -sensitive Simoa technology to support the research testing needs of our customers across a wide-range of applications and assays, including for neurology, oncology, infectious disease, and a wide range of critical biomarkers that can be used to track disease biology. We invite researchers whose in-house testing has been interrupted or who have emergent testing needs to contact Andy Keys (akeys@quanterix.com) to learn how our services can overcome interruptions or emergency testing needs.

Latest Publications

Samples require no pretreatment, no special handling and no molecular laboratory measures against carryover contamination associated with amplification methods.
Frontiers in Cellular and Infection Microbiology. 2019;9.

Latest News

03.27
The sudden COVID-19 pandemic has prompted Quanterix to implement sweeping changes at an unprecedented pace. The time is now to unite our global community, take bold steps to halt the spread of this outbreak and minimize long-term impacts on global health.