NfL levels predominantly increase at disease onset in MOG-Abs-associated disorders
Multiple Sclerosis & Related Disorders | February 11, 2021
Mariotto S, Gastaldi M, Grazian L, Mancinelli C, Ruggero C, Romain M, Alberti D, Zanzoni S, Schanda K, Franciotta D, Calabria F, Monaco S, Reindl M, Ferrari S and Gajofatto A
Mult Scler Relat Disord. 2021 Feb 11;50:102833
The unpredictable course and uncertain impact of relapses make treatment strategies of anti-myelin oligodendrocyte glycoprotein antibodies associated disorders (MOGAD) challenging. We analysed neurofilament light chain levels (NfL) in onset and follow-up sera of 18 patients with MOGAD to clarify the timing of axonal damage. In comparison with disease onset values (median 8.9 pg/mL, range 1.8-97), NfL levels remained stable or decreased in most follow-up measurements (n=52, median 6.7 pg/mL, range 0.2-207), including those measured on relapses. The predominant axonal damage occurs during onset, which could be the main driving factor of final disability, with subsequent relevant clinical and therapeutic implications.
Share this page