Intraindividual Neurofilament Dynamics In Serum Mark The Conversion To Sporadic Parkinson’s Disease
MOVEMENT DISORDER SOCIETY
Wilke C, Dos Santos MCT, Schulte C, Deuschle C, Scheller D, Verbelen M, Brockmann K, von Thaler AK, Sunkel U, Roeben B, Bujac S, Metzger FG, Maetzler W, da Costa AN, Synofzik M and Berg D
Mov Disord. 2020 Apr 27
Background And Objectives
With disease‐modifying treatment strategies on the horizon, stratification of individual patients at the earliest stages of Parkinson’s disease (PD) is key—ideally already at clinical disease onset. Blood levels of neurofilament light chain (NfL) provide an easily accessible fluid biomarker that might allow capturing the conversion from prodromal to manifest PD.
We assessed longitudinal serum NfL levels in subjects converting from prodromal to manifest sporadic PD (converters), at‐risk subjects, and matched controls (72 participants with ≈4 visits), using single‐molecule array (Simoa) technique.
While NfL levels were not increased at the prodromal stage, subjects converting to the manifest motor stage showed a significant intraindividual acceleration of the age‐dependent increase of NfL levels.
The temporal dynamics of intraindividual NfL blood levels might mark the conversion to clinically manifest PD, providing a potential stratification biomarker for individual disease onset in the advent of precision medicine for PD.