Publications & Posters

Changes in Blood Biomarkers of Brain Injury and Degeneration Following Long-Duration Spaceflight

JAMA Neurology | October 11, 2021

Zu Eulenburg P, Buchheim JI, Ashton NJ, Vassilieva G, Blennow K, Zetterberg H and Choukér A

JAMA Neurol. 2021


Long-duration spaceflight has a widespread effect on human physiology. The past decade first revealed eyeball alterations, and then neuroimaging studies hinted at potentially detrimental effects on the brain.1,2 Expansion of cerebrospinal fluid spaces occurs at the cost of the gray and white matter compartment. A neurobiological integrity assessment of the brain’s tissues after prolonged exposure to microgravity has never been conducted, to our knowledge. Therefore, we investigated the longitudinal course of blood-based biomarkers representing the brain parenchyma in long-duration spaceflight.