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Neurofilament light (NfL) — Plasma Neurofilament Light Chain (NfL) Assay


Neurofilament light (NfL) is a cytoskeletal intermediate filament protein that is expressed in neurons an associates with the neurofilament medium (NfM) and the neurofilament heavy (NfH) to form neurofilaments. Neurofilaments can be released in significant quantities following axonal damage or neuronal degeneration and NfL has been shown to be associated with traumatic brain injury, multiple sclerosis, frontotemporal dementia and other neurodegenerative diseases.