May 2021 Simoa® Publications: Alzheimer’s Disease and Multiple Sclerosis

Transitioning from cerebrospinal fluid to blood tests to facilitate diagnosis and disease monitoring in Alzheimer’s disease

Alawode DOT, et al.
J Intern Med. 2021 May 22.

Alzheimer’s Disease

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Astrocyte Biomarkers in Alzheimer Disease: A Systematic Review and Meta-analysis

Bellaver B, et al.
Neurology. 2021

Alzheimer’s Disease

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Development of immunoprecipitation – two-dimensional liquid chromatography – mass spectrometry methodology as biomarker read-out to quantify phosphorylated tau in cerebrospinal fluid from Alzheimer disease patients

Bijttebier S, et al.
Journal of Chromatography A. 2021:462299

Alzheimer’s Disease

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NFL strongly correlates with TNF-R1 in the plasma of AD patients, but not with cognitive decline

Delaby C, et al.
Sci Rep. 2021;11:10283

Alzheimer’s Disease

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Saliva Neurofilament Light Chain Is Not a Diagnostic Biomarker for Neurodegeneration in a Mixed Memory Clinic Population

Gleerup HS, et al.
Front Aging Neurosci. 2021;13

Alzheimer’s Disease

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Water exchange rate across the blood-brain barrier is associated with CSF amyloid-β 42 in healthy older adults

Gold BT, et al.
Alzheimer’s & Dementia : The Journal of the Alzheimer’s Association. 2021

Alzheimer’s Disease

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Characterization of Alzheimer’s tau biomarker discordance using plasma, CSF, and PET

Guo Y, et al.
Alzheimers Res Ther. 2021;13:93

Alzheimer’s Disease

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Blood-brain barrier breakdown in relationship to Alzheimer and vascular disease

Lin BSZ, et al.
Ann Neurol. 2021 May 26

Alzheimer’s Disease

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Biomarkers and Their Implications in Alzheimer’s Disease: A Literature Review

Marcucci V and Kleiman J
Exploratory Research and Hypothesis in Medicine. 2021

Alzheimer’s Disease

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Serum neurofilament levels reflect outer retinal layer changes in multiple sclerosis

Seitz CB, et al.
Therapeutic Advances in Neurological Disorders. 2021;14:17562864211003478

Multiple Sclerosis

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Highly specific and ultrasensitive plasma test detects Abeta(1-42) and Abeta(1-40) in Alzheimer’s disease

Thijssen EH, et al.
Sci Rep. 2021;11:9736

Alzheimer’s Disease

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Low serum neurofilament light chain values identify optimal responders to dimethyl fumarate in multiple sclerosis treatment

Walo-Delgado PE, et al.
Sci Rep. 2021 Apr 29;11(1):9299

Multiple Sclerosis

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Large-scale plasma proteomic profiling identifies a high-performance biomarker panel for Alzheimer’s disease screening and staging

Jiang Y, et al.
Alzheimers Dement. 2021 May 25

Alzheimer’s Disease

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A neurologist’s perspective on serum neurofilament light in the memory clinic: a prospective implementation study

Willemse EAJ, et al.
Alzheimers Res Ther. 2021 May 18;13(1):101

Alzheimer’s Disease

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May 2021 Simoa® Publications in Other Therapeutic Areas