Beyond Blood: Tear Fluid as a Window into Biomarker Discovery 

While blood and CSF have long dominated biomarker research, tear fluid is emerging as a scientifically relevant, non-invasive matrix for detecting systemic and neurological biomarkers. Produced by lacrimal glands and influenced by neural, immune, and endocrine pathways, tears contain cytokines and neuronal proteins that reflect both local and central pathophysiology.

With Simoa®’s ultra-sensitive immunoassay technology, researchers can now quantify low-abundance biomarkers in microliter volumes of tear fluid—opening new avenues in inflammation and neurodegeneration research.

In this app note, you’ll learn how:

• Tear cytokine levels reflect immune imbalance in ocular and systemic conditions
• α-synuclein and NfL in tears provide insight into Parkinson’s disease pathology
• Simoa enables robust detection in low-volume, non-invasive biofluids

Download your copy of the application note and explore how tears and Simoa^® are redefining the future of immune monitoring.