Saliva as a Noninvasive Matrix for Immune Surveillance and Infectious Disease Research via Ultra-Sensitive Antibody Detection

Unlock Saliva’s Potential in Immune Monitoring

Ultra-sensitive Simoa technology makes noninvasive, scalable, and high-fidelity immune profiling a reality.

Immune monitoring has long depended on venous blood draws—accurate but limited by infrastructure, cost, and patient burden. Now, saliva is emerging as a scientifically validated alternative, carrying both systemic (IgG) and mucosal (IgA) immune markers. Paired with the unmatched sensitivity of Quanterix’s Simoa® platform, saliva becomes more than a convenient matrix, it becomes a powerful tool for precision research.

In this application note, you’ll discover:

• How saliva-based assays deliver sub-picogram sensitivity without complex sample preparation.
• Data demonstrating saliva’s strong correlation with serum in vaccine response monitoring.
• Why saliva enables repeat, decentralized, and population-scale immune studies.
• Key applications across vaccine R&D, public health surveillance, pediatrics, geriatrics, and decentralized clinical trials.

Validated in peer-reviewed studies, saliva-based Simoa^® assays open new possibilities for scalable, noninvasive immune monitoring, without sacrificing rigor, reproducibility, or analytical depth.

Download your copy of the application note and explore how saliva and Simoa^® are redefining the future of immune monitoring.