Vascular endothelial growth factor C (VEGF-C) is a member of the platelet-derived growth factor / vascular endothelial growth factor (PDGF/VEGF) family. It promotes lymphogenesis and angiogenesis through its receptors, VEGFR-3 and VEGFR-2, and plays an important role in both neuronal development and blood pressure regulation. Lack of VEGF-C results in lymphedema, whilst increased expression of VEGF-C is implicated in tumor angiogenesis and metastasis.