Tumor Necrosis Factor Receptor 2


Tumor Necrosis Factor Receptor 2, also known as TNFRII or CD120, is a type I transmembrane protein belonging to the TNF superfamily. Both TNFRI and TNFRII are co-expressed with TNFRI ubiquitously expressed throughout many cell types. TNFRII on the other hand is primarily expressed within immune cells and certain endothelial cells. Both receptors can also exist in soluble forms by proteolytic shedding of the extracellular portion of the receptors by the tumor necrosis factor alpha converting enzyme (TACE/ADAM17).

The soluble forms of both TNFRI and TNFRII have been found to neutralize the activity of TNFα thus inhibiting the TNFα-mediated proinflammatory effects. Circulating sTNFRI and sTNFRII are elevated in many disease types including the two autoimmune inflammatory diseases ulcerative colitis and Crohn’s disease.