MMP-2

MMP-2 (matrix metalloproteinase-2), also known as gelatinase A, is a 72 kDa enzyme which is encoded by the MMP2 gene. Its main function is to degrade collagens to switch on different patterning mechanisms for VEGF-C. It can also degrade matrix proteins decorin, elastin, and fibronectin. MMP-2 modulates the functions of many vasoactive and proinflammatory molecules such as Adrenomedullin, MCP-3, and SDF-1.