KC, better known as chemokine (C-X-C motif) ligand 1 (CXCL1), is a small cytokine that belongs to the CXC chemokine family. It is expressed by macrophages, neutrophils, and epithelial cells and secreted by human melanoma cells. CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, arteriogenesis, inflammation, wound healing, and tumorigenesis. Dysregulation of CXCL1 has shown to be correlated with tumors, lung infections, pulmonary diseases and more.