Heparin-binding epidermal growth factor (HB-EGF), part of the EGF family of growth factors, is a mitogenic and chemotactic glycoprotein. HB-EGF is essential for normal cardiac valve formation and heart function as well as cutaneous wound healing. Research suggests that HB-EGF plays a critical role in the formation of many types of tumors as well as neurogenesis once the propeptide is induced by brain hypoxia or ischemia.