High Sensitivity Cardiac Troponin Assays in the Clinical Laboratories

Clinical Chemistry and Laboratory Medicine | October 22, 2014

Petr Jarolim
Clinical Chemistry and Laboratory Medicine 2014
DOI:  10.1515/cclm-2014-0565

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Abstract: Immunoassays measuring cardiac troponins I or T have become firmly established as critical tools for diagnosing acute myocardial infarction. While most contemporary assays provide adequate diagnostic performance, the increased sensitivity and precision of the new, high sensitivity assays that have already been introduced into clinical practice, provide the potential to further shorten intervals between blood draws or the time needed to detect the first significant troponin elevation. In addition to the relatively modest benefits at the diagnostic end, the high sensitivity assays and the investigational ultrasensitive cardiac troponin assays offer improvements for predicting major adverse cardiovascular events, development of heart failure or transition to end-stage kidney disease..