Trem2 deletion reduces late-stage amyloid plaque accumulation, elevates the Abeta42:Abeta40 ratio, and exacerbates axonal dystrophy and dendritic spine loss in the PS2APP Alzheimer's mouse model.

The Journal of Neuroscience
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Meilandt WJ, Ngu H, Gogineni A, Lalehzadeh G, Lee SH, Srinivasan K, Imperio J, Wu T, Weber M, Kruse AJ, Stark KL, Chan P, Kwong M, Modrusan Z, Friedman BA, Elstrott J, Foreman O, Easton A, Sheng M and Hansen DV.

The Journal of Neuroscience : The Official Journal of the Society for Neuroscience. 2020.

DOI: https://doi.org/10.1523/JNEUROSCI.1871-19.2019

ABSTRACT