Plasma neurofilament light in progressive multiple sclerosis

Acta neurologica Scandinavica. 2019.

Zetterberg H.

Acta Neurol Scand. 2019 Oct 16. doi: 10.1111/ane.13184.


Neurofilaments (Nfs) are a family of neuronal intermediate filaments involved in the growth and stability of axons, and, through incorporation into different supramolecular assemblies, also in synaptic organization and function in the central nervous system. Pioneering work by Lars Rosengren and colleagues in the late 1980s led to the establishment of an enzyme-linked immunosorbent assay (ELISA) based on polyclonal antisera that allowed for the reliable quantification of the neurofilament light (NfL) subunit in cerebrospinal fluid (CSF).