Type I interferons (IFNs) are essential mediators of antiviral responses. These cytokines have been implicated in the pathogenesis of autoimmunity, most notably systemic lupus erythematosus (SLE), diabetes mellitus, and dermatomyositis, as well as monogenic type I interferonopathies.
Resources by Therapeutic Area
The Journal of Experimental Medicine | April 18, 2017
Journal of Experimental Medicine | April 18, 2017
Measurement of IFNα attomolar concentrations by digital ELISA will enhance our understanding of IFN biology and potentially improve the diagnosis and stratification of pathologies associated with IFN dysregulation.
Evaluation Of Th2 And Th17 Cytokine Levels In Serum From Asthmatics Using The High Sensitivity Quanterix Simoa HD-1 Platform
American Thoracic Society | May 15, 2016
This study investigated the capability of the Quanterix Simoa HD-1 to measure interleukin (IL)-5 , - 13, and -17A in serum samples to determine if increasing assay sensitivity will allow us to convincingly detect these cytokines at baseline.
Development of an ultra-sensitive Simoa assay to enable GDF11 detection: a comparison across bioanalytical platforms
Bioanalysis | February 26, 2016
Four bioanalytical platforms were evaluated to optimize sensitivity and enable detection of recombinant human GDF11 in biological matrices. Simoa achieved the greatest sensitivity, an improvement of 100-fold over the next sensitive platform.