Water exchange rate across the blood-brain barrier is associated with CSF amyloid-β 42 in healthy older adults
Alzheimer’s & Dementia | May 5, 2021
Gold BT, Shao X, Sudduth TL, Jicha GA, Wilcock DM, Seago ER and Wang DJJ
Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 2021
We tested if water exchange across the blood-brain barrier (BBB), estimated with a noninvasive magnetic resonance imaging (MRI) technique, is associated with cerebrospinal fluid (CSF) biomarkers of Alzheimer’s disease (AD) and neuropsychological function.
Forty cognitively normal older adults (67–86 years old) were scanned with diffusion-prepared, arterial spin labeling (DP-ASL), which estimates water exchange rate across the BBB (kw). Participants also underwent CSF draw and neuropsychological testing. Multiple linear regression models were run with kw as a predictor of CSF concentrations and neuropsychological scores.
In multiple brain regions, BBB kw was positively associated with CSF amyloid beta (Aβ)42 concentration levels. BBB kw was only moderately associated with neuropsychological performance.
Our results suggest that low water exchange rate across the BBB is associated with low CSF Aβ42 concentration. These findings suggest that kw may be a promising noninvasive indicator of BBB Aβ clearance functions, a possibility which should be further tested in future research.
This study was performed using the Quanterix HD-1 Analyzer.
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