AAIC 2017

Lei Chang, Dandan Shan, Jason Wickman, Marcella Holdridge, Christina Raso, David Wilson 

Background:

Tau and Amyloid beta have been considered as major proteins that related to Alzheimer’s disease pathology. Blood Tau only became reliably detected recently. Multiplexed measurement of Amyloid beta1-42 (Aβ 42), Amyloid beta1-40 (Aβ40) and total tau in serum, plasma and CSF continues to be challenging, especially for normal healthy individual. Here we report  an automatic multiplexing assay of total Tau, Amyloid beta 1-42 and Amyloid beta 1-40. This fully automated digital immunoassay can measure above 3 biomarkers in serum, plasma and CSF in both healthy and diseased individuals.