Journal Of Neurotrauma | August 19, 2016
Ljunggvist JC, Zetterberg H, Mitsis M, Blennow K, Skoglund TS.
Journal of Neurotrauma
Diffuse axonal injury (DAI) is an important cause of morbidity in patients with traumatic brain injury (TBI). There is a lack of a simple and reliable technique to early identify patients with DAI and to prognosticate long-term outcome in this patient group. In the present study we examined acute serum concentrations of NFL (neurofilament light) in nine patients with severe TBI and DAI using a novel ultrasensitive Single molecule array (Simoa) assay. The relationships between the NFL concentrations and MRI in the acute stage as well as clinical outcome and MR-DTI parameters at 12 months were analysed. We found that the mean NFL concentrations among the patients displayed a 30-fold increase compared to the controls and that the NFL completely discriminated between the patients and the controls. We also found a relation between serum NFL and MR-DTI parameters, with higher NFL concentrations in patients with higher trace (R2=0.79) and lower FA (R2=0.83). These results suggest that serum NFL may be a valuable blood biomarker for TBI reflecting the severity of DAI.
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