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Plasma Neurofilament Light Chain Predicts Progression In Progressive Supranuclear Palsy

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Annals Of Clinical And Translational Neurology | March 3, 2016

Julio C. Rojas et. al.
Annals of Clinical and Translational Neurology
DOI: 10.1002/acn3.290

Objective: Blood‐based biomarkers for neurodegenerative conditions could improve diagnosis and treatment development. Neurofilament light chain (NfL), a marker of axonal injury, is elevated in cerebrospinal fluid (CSF) of patients with progressive supranuclear palsy (PSP). The goal of this study was to determine the diagnostic and prognostic value of plasma NfL in patients with PSP.