Publications & Posters

Intrathecal Nusinersen Treatment After Ventriculo-peritoneal Shunt Placement: A Case Report Focusing On The Neurofilament Light Chain In Cerebrospinal Fluid


Tozawa T, Kasai T, Tatebe H, Shiomi K, Nishio H, Tokuda T and Chiyonobu T.

Brain Dev. 2019 Dec 28. pii: S0387-7604(19)30714-4.

DOI: 10.1016/j.braindev.2019.12.006



In July 2018, a rare and serious adverse effect (AE), namely, communicating hydrocephalus unrelated to meningitis or bleeding, was reported in relation to five patients treated with nusinersen for spinal muscular atrophy (SMA). Some patients were managed using a ventriculo-peritoneal shunt (VPS) implant and continued to receive nusinersen treatment. However, there is limited information concerning the effectiveness and safety of nusinersen treatment for patients with a VPS.

Case Report

A female patient exhibited general hypotonia soon after birth and was diagnosed, using genetic analysis, with spinal muscular atrophy. She required permanent invasive ventilation from 2 months of age. She developed a progressive hydrocephalus and underwent placement of a VPS in infancy. Treatment with nusinersen was initiated when she was 7 years old. The neurofilament light-chain (NfL) concentration in the cerebrospinal fluid (CSF) decreased over time with nusinersen treatment. Twelve months have passed since the start of nusinersen treatment and no AEs have been observed.


Nusinersen treatment may be effective and safe, even after placement of a VPS. NfL levels in the CSF could be valuable markers of disease activity/treatment response even in advanced stages of SMA.