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Differential Immunodetection Of Toxin B From Highly Virulent Clostridium Difficile Bi/nap-1/027

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Journal Of Clinical Microbiology | February 25, 2015

Pollock NR, Song L, Zhao M, Duffy DC, Chen X, Sambol SP, Gerding DN, Kelly CP
Journal of Clinical Microbiology 53:1705–1708
DOI: 10.1128/JCM.03419-14

We developed a simple immunoassay capable of differentially detecting toxin B from highly virulent strains of Clostridium difficile(BI/NAP-1/027) in stool. This assay can simultaneously confirm the presence of in vivo toxin production and provide strain related information relevant to infection control epidemiology and disease prognosis.