Development Of An Ultrasensitive Digital Immunoassay For The Measurement Of Lrrk2 In Cerebral Spinal Fluid (CSF)
Nathan Estochen, Dipika Gemani, Melissa Berman, Linan Song, David Hanlon, Andreas Jeromin, Danielle Graham
Presented at AAIC 2017 London
Parkinson’s disease (PD), like other neurological disorders, has been recognized to have a genetic component. Mutations in the leucine-rich repeat kinase-2 (LRRK2) gene are recognized as genetic risk factors for familial PD, and may also represent causal factors in the more common sporadic form of the disease. The central role of LRRK2 in genetic and idiopathic PD has led to significant interest in further characterizing LRRK2 at both the genetic and protein levels.