Biomarkers in Islet Cell Transplantation for Type 1 Diabetes.
CURRENT DIABETES REPORTS. 2018;18:94. | SEPTEMBER 05, 2018
AlRashidi FT and Gillespie KM.
Curr Diab Rep. 2018 Sep 5;18(10):94. doi: 10.1007/s11892-018-1059-4.
PURPOSE OF REVIEW:
Islet transplantation, an important approach to achieve insulin independence for individuals with type 1 diabetes, is limited by the lack of accurate biomarkers to track beta-cell death post islet infusion. In this review, we will discuss existing and recently described biomarkers.
As beta cells are killed by the immune system, fragments of beta cell-specific cell-free DNA and proteins are released into the periphery. Several different strategies to identify these fragments have been described. Some circulating, non-coding microRNAs, particularly miRNA-375 are also showing potential to reflect the rate of beta cell loss post-clinical islet transplantation. Recent advances in identifying accurate beta cell-specific biomarkers such as differentially methylated insulin cell-free DNA and circulating miRNA-375 may help predict clinical outcomes. More studies are required to examine the robustness of these biomarkers to detect chronic beta-cell loss in islettransplantation recipients.