PD-1

PD-1

Programmed cell death protein 1 (PD-1 or CD279) is a cell surface receptor that belongs to the immunoglobulin superfamily and is expressed on T cells, B cells, monocytes, and dendritic cells. PD-1 plays an important role as an immune checkpoint. PD-1 binds to two ligands, PD-L1 and PD-L2. The PD-1/PD-L1 or PD-L2 signaling pathway is a negative regulatory mechanism that inhibits T cell proliferation and cytokine production. PD-1 inhibitors play a role in activation of the immune system and can be used for cancer treatment. Blockade of the PD- 1/PD-L1 interaction enhances anti-tumor immunity and shows potential for improving cancer immunotherapy . The PD-1 pathway plays a major role in the inhibition of self-reactive T cells and protection against autoimmune diseases. Rheumatoid arthritis patients were shown to have significantly elevated plasma levels of sPD-1. Serum sPD-1 levels positively correlated with the severity of skin sclerosis. Autoimmune hepatitis patients with active disease and incomplete response to standard treatment showed increased sPD-1 levels . PD-1 was also shown to be a regulator of virus-specific CD8+ T cell survival in HIV infection.

Safety Data Sheets

The following Safety Data Sheets are associated with this Assay.

Certificates of Analysis

The following Certificates of Analysis are associated with this Assay.