C-Peptide

C-Peptide

The connecting Peptide, or C-Peptide, is a short 31-amino-acid protein that connects insulin’s A-chain to its B-chain in the proinsulin molecule. Patients with diabetes may have their C-Peptide levels measured as a means of distinguishing Type 1 diabetes from Type 2 diabetes or Maturity Onset Diabetes of the Young (MODY). Serum C-Peptide levels correlate with endogenous insulin production and surviving β-cells and are present in equimolar amounts. Ultrasensitive assays reveal C-Peptide production persists for decades after Type 1 disease onset and remains functionally responsive in patients with advanced disease, whose β-cells function was thought to have ceased. C-Peptide levels are measured instead of insulin levels because C-Peptide can assess a person’s own insulin secretion even if they receive insulin injections, and because the liver metabolizes a larger and variable amount of insulin secreted into the portal vein but does not metabolize C-Peptide, which means that blood C-Peptide may be a better measure of portal insulin secretion than insulin itself.

Safety Data Sheets

The following Safety Data Sheets are associated with this Assay.

Certificates of Analysis

The following Certificates of Analysis are associated with this Assay.