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Simoa® p-Tau 217 Fact Sheet


Phosphorylated Tau 217 (p-Tau 217) is proving to be a crucial biomarker for Alzheimer’s disease and other neurodegenerative disorders. Tau proteins play a pivotal role in maintaining the stability of neuronal microtubules, which are essential for normal brain function. In Alzheimer’s disease, tau proteins can become hyperphosphorylated, leading to the formation of neurofibrillary tangles, a hallmark of the disease. This abnormal phosphorylation is associated with neuronal damage, cognitive decline, and cell death.

Research indicates that p-Tau 217 levels in cerebrospinal fluid (CSF) and blood are significantly elevated in patients with Alzheimer’s, even in the early stages. This positions it as a valuable potential biomarker for early diagnosis and monitoring disease progression. Furthermore, studies have shown that p-Tau 217 can help differentiate Alzheimer’s disease from other forms of dementia, such as Lewy body dementia and frontotemporal dementia. Download our fact sheet to learn more.