Neurofilament light chains (NfL) are unique to neuronal cells, are shed to the CSF and are detectable at low concentrations in peripheral blood. Various diseases causing neuronal damage have resulted in elevated CSF concentrations. We explored the value of an ultrasensitive single-molecule array (…
Publications & Posters
Annals of Neurology | May 16, 2017
Serum concentrations of the axonal injury marker neurofilament light protein are not influenced by blood-brain barrier permeability
Brain Research | May 15, 2017
A blood biomarker to monitor individual susceptibility to neuronal injury from cranial radiotherapy could potentially help to individualize radiation treatment and thereby reduce the incidence and severity of late effects.
Bioanalysis | May 10, 2017
Ligand-binding techniques such as immunoassays, the reference for clinical diagnosis, offer a wide range of innovative approaches based on signal DNA amplification, nanotechnologies or digital assays, which result in technologies with sensitivities more than 1000-times that of formats used 20 years…
American Journal of Respiratory and Critical Care Medicine | May 2017
Poster Presentation, American Thoracic Society Conference 2017 A.26 Diagnosis and Treatment of Tuberculosis, Poster Session: May 21, 2017
Regulated Bioanalysis: Fundamentals and Practice | April 26, 2017
Johanna Mora, Charles Hottenstein, Binodh DeSilvaRegulated Bioanalysis: Fundamentals and Practice Volume 26 of the series AAPS Advances in the Pharmaceutical Sciences series
Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy
Science Translational Medicine | April 19, 2017
Tauopathies are a group of disorders in which the cytosolic protein tau aggregates and accumulates in cells within the brain, resulting in neurodegeneration. A promising treatment being explored for tauopathies is passive immunization with anti-tau antibodies.
The Journal of Experimental Medicine | April 18, 2017
Type I interferons (IFNs) are essential mediators of antiviral responses. These cytokines have been implicated in the pathogenesis of autoimmunity, most notably systemic lupus erythematosus (SLE), diabetes mellitus, and dermatomyositis, as well as monogenic type I interferonopathies.
Neuroscience Letters | April 18, 2017
Plasma neurofilament light (NFL) levels may be a marker of neuronal injury. We examined whether plasma NFL might be a potential biomarker for the prodromal and dementia stages of AD.
The Journal of Experimental Medicine | April 17, 2017
Tauopathies are characterized by the progressive accumulation of hyperphosphorylated, aggregated forms of tau. Our laboratory has previously demonstrated that passive immunization with an anti-tau antibody, HJ8.5, decreased accumulation of pathological tau in a human P301S tau-expressing transgenic…
Neurology | April 12, 2017
The results from these 2 independent cohort studies suggest that serum NFL is a highly sensitive biomarker for concussion.