Synaptic Dysfunction May Be the Missing Piece in Neurodegeneration
For decades, amyloid-β and tau biomarkers have transformed our understanding of Alzheimer’s disease. Yet these markers explain only part of what ultimately matters most: cognitive decline.
A growing body of evidence points to synaptic dysfunction as the biological process most closely linked to cognitive impairment across neurodegenerative diseases. Among emerging synaptic biomarkers, Neuronal Pentraxin 2 (NPTX2) has rapidly gained attention as a powerful indicator of synaptic integrity, network function, and cognitive resilience.
Download the Publication Brief
Discover the latest research highlighting NPTX2 as a biomarker for:
- Synaptic degeneration and circuit dysfunction
- Cognitive decline and disease severity
- Brain atrophy and neurodegeneration
- Progression from normal cognition to MCI and dementia
- Cognitive resilience independent of amyloid burden
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