Applying spatial biology to neuroscience research presents unique challenges due to limited tissue availability and the fragile nature of brain tissue. Akoya Biosciences has been working to address these challenges so that researchers can visualize cellular relationships and molecular context within brain tissue. In this webinar, learn how ultrahigh-plex spatial phenotyping has been applied to neurodegenerative disease research.
The following papers are highlighted in this webinar:
- Heinrich L, Zafar F, Morato Torres CA, et al. Multiplex imaging of human induced pluripotent stem cell-derived neurons with CO-Detection by indEXing (CODEX) technology. J Neurosci Methods. 2022;378:109653. doi:10.1016/j.jneumeth.2022.109653
- Sanchez-Molina P, Pratapa A, Nikulina N, et al. Single-cell spatial proteomic analysis by multiplexed imaging enables identification of microglial heterogeneity in Alzheimer’s disease human brain. Research Square. Posted May 2, 2023. doi:10.21203/rs.3.rs-2870341/v1
Explore our ready-to-use Mouse Neurobiology PhenoCode Discovery Panel featuring 40+ validated biomarkers for deep spatial phenotyping of neurons, glial populations, and immune cells in mouse tissue.
Discover our off-the-shelf Human Neurobiology PhenoCode Discovery Panel that includes 42 key neuro biomarkers enabling detection of neurodegenerative protein aggregates associated with Alzheimer’s disease and Parkinson’s disease, tracking of inflammation-driven pathology, and assessment blood-brain barrier integrity disruptions.
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