Immune checkpoint inhibitors have emerged as an effective treatment for various cancer types. Anti-PD-1/PD-L1 immune checkpoint inhibitor therapy provides a durable effect when given to patients likely to respond, however, identifying these patients remains a challenge. Therefore, focusing on developing a consistently predictive biomarker to guide patient selection for highly targeted checkpoint inhibitor therapies is key.
In this webinar, Dr. Arutha Kulasinghe, NHMRC Research Fellow and Clinical-oMx Group Leader at the Frazer Institute, University of Queensland, will discuss how single-cell multiomic spatial phenotyping is an invaluable tool to characterize the tumor microenvironment using unbiased whole-slide imaging of metastatic/recurrent HNSCC tumors among patients treated with pembrolizumab/nivolumab. He will also explain how using these techniques, his team were able to identify stromal, immune, and metabolic tissue signatures associated with resistance to immunotherapy and poor overall survival.
Learning Objectives:
- Understand spatial biology approaches
- Learn how to profile deep tumor microenvironments
- Understand how to decode immunotherapy responses
- Discover applications for skin, lung and head, and neck cancer
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