Achieving effective and sustainable anti-tumor immunity remains a significant challenge in cancer therapy, largely due to tumor immunosuppression. This is particularly pronounced in brain tumors, which create one of the most immunosuppressive tumor microenvironments. A key player in this process are macrophages, which can shift between a pro-inflammatory M1-like state and a pro-tumor M2-like state, contributing to the suppression of immune responses.
In this webinar, we present the latest research on reprogramming the brain tumor microenvironment to enhance anti-tumor immunity. Using advanced spatial tissue analysis combined with in vitro experiments, we will delve into the mechanisms regulating macrophage-dependent tumor immunosuppression in brain cancer. Our findings reveal that the spatial localization of macrophages within the tumor microenvironment influences their functional state, and that pathological tissue remodeling within perivascular niches impacts the activity of tumor-infiltrating lymphocytes.
Learning Objectives:
- Impact of the brain tumor microenvironment on immune cells
- The role of macrophages in tumor immunosuppression
- How tissue remodeling could enhance anti-tumor immunity in brain cancer
Related Posts
Accelerate Building Custom Spatial Proteomic Panels for New Biological Insights
Ultrasensitive Neuroimmune Biomarker Measurement for Translational Research and Therapeutic Development
Underdiagnosis of Alzheimer’s disease pathology in patients with cardiovascular disease
Decoding Neurodegeneration: High-plex Spatial Proteomics Reveal Distinct Cell Phenotypes and Pathological Signatures in Parkinson’s and Alzheimer’s Disease
In this webinar, Dr. Birgitt Schuele, Associate Professor (Research) of Pathology at Stanford University, showcases how ultrahigh-plex spatial proteomics is being used to uncover distinct cell phenotypes and pathological signatures…
Understanding the Brain: Advancing Neurodegeneration Research with Ultrahigh-Plex Spatial Proteomics
In this webinar, learn how ultrahigh-plex spatial phenotyping has been applied to neurodegenerative disease research.
p-Tau 205 and p-Tau 212: Emerging Biomarkers for Alzheimer’s Disease Research
Spatial Awareness: AI-powered Profiling of Trillions of Immune Cell Distribution Data Points Reveals Key Predictors of Cancer Recurrence Risk
This webinar highlights a groundbreaking study recently published as a Nature cover story (April 2025). Dr. Joe Yeong will describe how a pre-designed analytical framework—driven by well-defined clinical and scientific…
Multimodal Single-Cell Spatial Transcriptomics and Proteomics to Uncover the Biological Processes Driving Immunotherapy Response and Resistance in Renal Cancer
In this webinar, Dr. Anne-Laure Cattin from the Cancer Dynamics Laboratory at The Francis Crick Institute in London, will share her research on kidney cancer, focusing on the integration of…