Transformative technology doesn’t come along often, so when it does, scientists take notice. Spatial biology has rapidly changed how investigators study diverse cellular landscapes across multiple dimensions. This has allowed researchers to study cells in context with their localized environment—affording them novel biological insights. A thorough understanding of complex spatial host-disease interactions in situ is necessary to develop effective preventative measures and therapeutic strategies. In this webinar, originally broadcast by Genetic Engineering & Biotechnology News (GEN), Dr. Sizun Jiang shares data from a clinical cohort of cutaneous T cell lymphoma (CTCL) patients, in which he and his laboratory show how to robustly titrate and validate antibodies with the highly multiplexing capabilities of PhenoCycler™ (formerly CODEX®). Dr. Jiang will also describe how his findings can be extended to understanding immune-tumor interactions for a better understanding of immunotherapy responses and strategies in CTCL. Dr. Niro Ramachandran sets the stage for Dr. Jiang’s talk by discussing the need for new techniques that take full advantage of complementary technologies to unravel complex biological mechanisms in healthy and diseased tissues. In addition, he provides an overview of Akoya’s Imaging Innovators (I2) network, a first-of-its-kind collaboration of pioneering scientists from world-class research organizations with ambitions to advance the field of spatial biology.
You will learn
- Proven techniques for stringent and robust validation of markers for multiplexed imaging technologies such as PhenoCycler.
- Computational strategies for analysis of multiplexed PhenoCycler images
- How to design and incorporate multiplexed imaging experiments into current projects
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