Simoa Bead

 

Simoa Bead

The technology to measure biomarkers at lower levels than ever before

Quanterix’ digital biomarker detection technology, Simoa, is changing the way in which the biology of health and disease is studied by giving researchers the ability to examine critical proteins and nucleic acids, at ultra low - even baseline - levels, in most common sample types.

Detecting the Undetectable

Simoa, an ultra-sensitive immunoassay technology allows detection of proteins and nucleic acids at lowest possible levels.

First of its kind detection capabilities

This innovative technology is perfectly suited for single- and multi-plex detection of key biomarkers at ultra-low levels in applications within all therapeutic areas, including oncology, neurology, cardiology, immunology, and infectious disease.

First of its kind detection capabilities

Detect biomarkers at femtogram levels

The innovative digital nature of the technique allows an average of 1000 times sensitivity increase over conventional assays, with CVs less than 10 percent.

Detect biomarkers at femtogram levels

See results in record time

Incubation time for analyte capture and detector binding is typically about 30 minutes, with five minutes for labeling by the streptavidin β-galactosidase (SBG) conjugate.

See results in record time

The evolution of the immunoassay

Revolutionizing new discoveries with ultra-sensitive detection

SIMOA Bead and Planar Technology

Enable detection of thousands more targets for drug development, efficacy, and safety.

The evolution of the immunoassay

How it works

A high level look at a Simoa Bead-based assay, from development to data analysis.

Paramagnetic particles coupled with antibodies designed to bind to specific targets are added to the sample.

Detection antibodies – capable of generating fluorescent product – are added.

The objective is to form an immunocomplex consisting of the bead, bound protein, and detection antibody.

At low concentrations, each bead will contain one bound protein, or none.

The sample is loaded into arrays, in the Simoa disc, consisting of more than 200,000 microwells – each large enough to hold one bead.

Simoa Bead Technology

Enabling insight into the biology of health and disease