Tau is a microtubule-stabilizing protein primarily localized in neurons of the central nervous system but also expressed at low levels in astrocytes and oligodendrocytes. Tau consists of six isoforms in the human brain with molecular weights of 48,000 to 67,000 daltons, depending on the isoform.
Elevated tau in CSF is a hallmark of patients with neurodegenerative disease and severe head injuries, suggesting its extracellular release during neuronal damage and its role as a biomarker with specificity for brain injury. In Alzheimer’s disease (AD) and related neurodegenerative diseases, including chronic traumatic encephalopathy, tau is abnormally phosphorylated and aggregated into bundles of filaments. Threonine 181 is one of the phosphorylation sites of human tau protein (p-Tau 181). Research suggests p-Tau 181 is more strongly associated with AD markers than total tau.
The Quanterix Simoa® p-Tau 181 assay is validated for use in discovery and diagnostic research applications. The Simoa® p-Tau 181 assay targets the proline-rich region of the Tau protein, which is highly conserved amongst the tau isoforms. Assays are available for use on the Quanterix HD-X, HD-1, and SR-X instruments, which offer options ranging from benchtop assay prep to automated sample processing and high-throughput capabilities.
Our ready-to-use Simoa® kits contain all the reagents necessary to run your p-Tau 181 assays. Each kit contains enough reagents for 96 tests.
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