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Request Information on Simoa® Mammalian GFAP Advantage PLUS

Key Benefits: 

  • Species-agnostic performance for consistent GFAP detection across rodent and human studies. 
  • Exceptional sensitivity and wide dynamic range for accurate quantification of low-abundance GFAP in serum and plasma.
  • Ideal for translational neuroscience research, including neuroinflammation, neurodegeneration, and TBI. 
  • Seamless integration into multi-analyte panels to study complex CNS biomarker networks. 
  • Enables harmonized study designs, reducing data variability between preclinical and clinical phases. 

Applications and Intended Use 

The Simoa® Mammalian GFAP Advantage PLUS is a research-use-only (RUO) digital immunoassay intended for the measurement of GFAP in serum and EDTA plasma from both preclinical models and human samples. It is specifically designed to advance research in: 
 
– Translational neuroscience and neuroinflammation 
– Astrocyte activation and glial biology 
– Cross-species model validation 
– Preclinical biomarker discovery and bridging studies 

Assay Specifications 

Specification 

Value 

Compatible Instruments 

HD-X, SR-X

LOD (Limit of Detection) 

≤0.5 pg/mL (target) 

Analytical LLOQ 

≤0.5 pg/mL (target) 

Dynamic Range 

Target ≥ 5 logs (≥50,000 pg/mL ULOQ) 

Species Reactivity 

Human, mouse, rat, ±NHP, ±canine 

Sample Types 

Serum, EDTA plasma 

Sample Volume 

15 µL 

Format 

Single-plex RUO 

Kit Contents 

Each kit includes validated reagents and controls for 96 tests: 


– Capture and detector antibodies optimized for mammalian-conserved GFAP epitopes 
– Calibrators and quality controls 
– Diluent buffers 
– User manual and protocol 

Ready to Power Your Preclinical Research? 

Contact us to learn more about the Mammalian GFAP Advantage PLUS assay and how Quanterix can accelerate your translational neuroscience program.