Tau is a microtubule-stabilizing protein predominantly found in the central nervous system (CNS), but also present in peripheral tissues. While CSF T-Tau is a well-established diagnostic biomarker for AD, its performance as a blood-based biomarker is limited. Given that about 80% of Tau in blood originates from peripheral tissues, there is a critical need to selectively measure CNS-originated Tau, referred to as brain-derived Tau (BD-Tau). This selective measurement of BD-Tau enhances the specificity and accessibility of Tau as a biomarker for AD.
BD-Tau is comprised mainly of low molecular weight (M.W.) isoforms, which lack the large peptide insert from exon 4a found in peripheral tissue Tau isoforms. By selectively measuring these low M.W. Tau isoforms in circulation, BD-tau demonstrates excellent correlation with CSF T-Tau and holds unique potential in identifying AD-type neurodegeneration. Moreover, BD-Tau may aid in monitoring recovery following severe traumatic brain injury (sTBI) and ischemic stroke.
The Simoa® BD-Tau Advantage PLUS is a digital immunoassay intended for the measurement of BD-Tau in human plasma, serum, and CSF samples, facilitating research in neurodegenerative diseases.
The assay kit includes all necessary reagents and controls to perform 96 tests.
Flyer: Unlock New Insights with Selective Measurement of BD-Tau
BD-Tau as a Plasma Biomarker of Neurodegeneration in Alzheimer’s Disease
Simoa® Neurology 4-Plex D (N4PD) Advantage PLUS
Q: How does the BD-Tau Assay improve specificity in Tau measurement?
A: The assay selectively measures CNS-originated Tau, reducing interference from peripheral tissue Tau.
Q: Can the BD-Tau Assay be used for longitudinal studies?
A: Yes, it ensures reliable results for both large-scale and longitudinal studies.
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